Article
Genotypic prediction of resistant mutation in HIV-1 pol gene towards the antiretroviral drugs.
International journal of bioinformatics research and applications - 1 Jan 2011
Kumar Amit, Jadhav Chandrakant
Abstract excerpt
Mutation in HIV-1 pol gene confers the resistance to antiretroviral drugs. Three nucleotide sequences of HIV-1 pol gene products were selected and HIV BLAST was performed. Amino acid positions of 30 sequences were compared with HXB2 reference strain. Two sequences of protease show the major mutat...
Topics
- Algorithms
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Computational Biology
- Drug Resistance, Viral
- Genes, pol
- Genetic Variation
- Genotype
- HIV Infections
- HIV Integrase
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Models, Genetic
- Mutation
- Phylogeny
- pol Gene Products, Human Immunodeficiency Virus