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Article

Noncanonical BMP Signaling Regulates Cyclooxygenase-2 Transcription

25 Mar 2011

Abstract excerpt

Activation of p38 MAPK has been shown to be relevant for a number of bone morphogenetic protein (BMP) physiological effects. We report here the involvement of noncanonical phosphorylated mothers against decapentaplegic (Smad) signaling in the transcriptional induction of Cox2 (Ptgs2) by BMP-2 in mesenchymal cells and organotypic calvarial cultures. We demonstrate that different regulatory elements are required...

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Identifiers

PMID: 21436263
DOI: 10.1210/me.2010-0515

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