Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the Czech population.

doi:10.5507/bp.2015.029

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Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the Czech population.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Sept 2015

Uvirova Magdalena, Simova Jarmila, Kubova Barbora, Dvorackova Nina, Tomaskova Hana, Sedivcova Monika, Dite Petr

Abstract excerpt

AIMS: A germline SNP (rs61764370) is located in a let-7 complementary site (LCS6) in the 3'UTR of KRAS oncogene, and it was found to alter the binding capability of the mature let-7 microRNA to the KRAS mRNA. The aim of the study was to evaluate the frequency of the KRAS-LCS6 variant allele in different cancer types that included patients with colorectal cancer (CRC), breast cancer (BC), non-small cell lung...

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PMID: 26077004
DOI: 10.5507/bp.2015.029

Genes

KRAS
EGFR
BRAF

Variants

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