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CYP3A5*3 and MDR-1 C3435T single nucleotide polymorphisms in six Chinese ethnic groups.

Die Pharmazie - 1 Feb 2011

Lai Yong, Zhang Jing, Wang Yi-Xi, Wang Xue-Ding, Li Jia-Li, Wang Yin-Hui, Zeng Yan-Jun, Huang Min

Abstract excerpt

The prevalent CYP3A5 *3 and the functional multi-drug resistance gene (MDR1) C3435T show marked interethnic variation among Orientals, Caucasians and Africans. This study aimed to investigate the distribution of CYP3A5*3 and MDR1 C3435T among Chinese ethnic groups. Genotypes of the CYP3A5*3 and MDR1 C3435T were determined in 839 unrelated healthy Chinese subjects by using polymerase chain reaction-restriction...

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PMID: 21434577

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