Article
[Polymorphism of repair genes and cytogenetic radiation effects].
Radiatsionnaia biologiia, radioecologiia - 1 Jan 2000
Sal'nikova L E, Chumachenko A G, Vesnina I N, Lapteva N Sh, Kuznetsova G I, Abilev S K, Rubanovich A V
Abstract excerpt
For 99 healthy volunteers, the frequencies of spontaneous and y-induced (1 Gy in vitro) chromosome aberrations in blood lymphocytes were compared with the results of PCR-genotyping by 8 repair genes: XRCC1, XPD, ERCC1, APEXI, RAD23B, OGG1, ATM, Tp53 (in all, 10 polymorphic sites). The frequency of spontaneous aberrations of chromosome type increased additively with the number of copies of minor allele of excision...
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