Article
Polymorphisms in the neural nicotinic acetylcholine receptor α4 subunit (CHRNA4) are associated with ADHD in a genetic isolate.
Attention deficit and hyperactivity disorders - 1 May 2009
Wallis Deeann, Arcos-Burgos Mauricio, Jain Mahim, Castellanos F Xavier, Palacio Juan David, Pineda David, Lopera Francisco, Stanescu Horia, Pineda Daniel, Berg Kate, Palacio Luis Guillermo, Bailey-Wilson Joan E, Muenke Maximilian
Abstract excerpt
The neural nicotinic acetylcholine receptor α4 subunit (CHRNA4), at 20q13.2-q13.3, is an important candidate gene for conferring susceptibility to attention deficit/hyperactivity disorder (ADHD). Several studies have already looked for association/linkage between ADHD and CHRNA4 in different populations. We used the Pedigree Disequilibrium Test to search for evidence of association between ADHD and six SNP marker...
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