Article
Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder.
Genes, brain, and behavior - 1 Feb 2008
Lee J, Laurin N, Crosbie J, Ickowicz A, Pathare T, Malone M, Kennedy J L, Tannock R, Schachar R, Barr C L
Abstract excerpt
Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset psychiatric condition with a strong genetic component. Evidence from pharmacological, clinical and animal studies has suggested that the nicotinic system could be involved in the disorder. Previous studies have implicated the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in ADHD. Particularly, a polymorphism in the exon...
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