Article
Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes.
Current topics in microbiology and immunology - 1 Jan 1990
Wilson G L, Leiter E H
Abstract excerpt
The MSZ diabetic male mouse represents one of the most useful tools available to researchers interested in analyzing the consequences of insulin dependent diabetes in male mice. In contrast to the high mortality induced by single high doses of SZ, protracted administration of smaller SZ dosages yields a more stable diabetic condition. Moreover, in insulitis prone strains such as BKs, the model allows...
Topics
- Animals
- Diabetes Mellitus, Experimental
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Genotype
- Humans
- Immune System
- Islets of Langerhans
- Mice
- Streptozocin