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Article

The prevalence of, and molecular defects underlying, inherited protein S deficiency in the general population.

British journal of haematology - 1 Jun 2004

Beauchamp Nicholas J, Dykes Anne C, Parikh Nirzari, Campbell Tait R, Daly Martina E

Abstract excerpt

The molecular basis of protein S (PS) deficiency was investigated in seven of eight donors identified with persistently low plasma PS levels from a survey of PS levels in 3788 Scottish blood donors. PROS1 gene analysis identified at least one defect in six donors. Five were heterozygous for the Heerlen polymorphism predicting a Ser460Pro substitution. Haplotype analysis revealed the possibility that this allele...

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Identifiers

PMID: 15147381
DOI: 10.1111/j.1365-2141.2004.04961.x

Genes

PROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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