Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.

BMC medical genetics - 23 Mar 2011

Nielsen Lotte B, Pörksen Sven, Andersen Marie Louise M, Fredheim Siri, Svensson Jannet, Hougaard Philip, Vanelli Maurizio, Åman Jan, Mortensen Henrik B, Hansen Lars

Abstract excerpt

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type 1 diabetes. We investigated the association of the C1858T variant with residual beta-cell function (as assessed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to C-Peptide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Diabetes Mellitus, Type 1

Share to Enzyme-Linked Immunosorbent Assay

Share to Proinsulin

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 21429197
DOI: 10.1186/1471-2350-12-41
PMCID: PMC3072937

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.PMID 21429197Read ↗

The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.Semantic proximity Read ↗

Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes.Semantic proximity Read ↗

C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.Semantic proximity Read ↗

Preserved proinsulin production in homozygous protein tyrosine phosphatase nonreceptor type 22 C1858T variant type 1 diabetes: a possible explanation for absence of overt ketoacidosis despite omission of exogenous insulin.Semantic proximity Read ↗

Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.Semantic proximity Read ↗

Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype.Semantic proximity Read ↗

Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.Semantic proximity Read ↗

PTPN22 1858T allele is associated with younger age at onset of type 1 diabetes and is not related to subsequent thyroid autoimmunity.Semantic proximity Read ↗

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.Semantic proximity Read ↗

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.Semantic proximity Read ↗

Role of C1858T Polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian Children and Adolescents with Type 1 Diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.