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The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.

Diabetes care - 1 Jun 2008

Petrone Antonio, Spoletini Marialuisa, Zampetti Simona, Capizzi Marco, Zavarella Sara, Osborn John, Pozzilli Paolo, Buzzetti Raffaella

Abstract excerpt

OBJECTIVE: Evidence has been reported for a new susceptible locus for type 1 diabetes, the protein tyrosine phosphatase nonreceptor type 2 (PTPN22), which encodes a lymphoid-specific phosphatase. The aim of the study was to evaluate the influence of the C1858T variant of the PTPN22 gene on beta-cell function as measured by C-peptide levels from time of disease diagnosis through 12 months follow-up in a...

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Source

Identifiers

PMID: 18252906
DOI: 10.2337/dc07-1158

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.PMID 18252906Read ↗

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C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

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Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.Semantic proximity Read ↗

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.Semantic proximity Read ↗

PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.Semantic proximity Read ↗

Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.Semantic proximity Read ↗

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PTPN22 1858T allele is associated with younger age at onset of type 1 diabetes and is not related to subsequent thyroid autoimmunity.Semantic proximity Read ↗

Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.Semantic proximity Read ↗

Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.Semantic proximity Read ↗

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