Article
Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis.
Experimental dermatology - 1 Jun 2011
Lesiak Aleksandra, Kuna Piotr, Zakrzewski Marcin, van Geel Michael, Bladergroen Reno S, Przybylowska Karolina, Stelmach Iwona, Majak Pawel, Hawro Tomasz, Sysa-Jedrzejowska Anna, Narbutt Joanna
Abstract excerpt
BACKGROUND: Although filaggrin mutations are presently believed to play a key role in the development of atopic dermatitis (AD), obviously also immunological factors involved in acquired immune response are important for the development of allergic inflammation. OBJECTIVE: To assess the frequency of FLG mutations and the polymorphisms 590 C/T in the IL-4 gene, -1082A/G in the IL-10 gene and -1055C/T in the IL-13...
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