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Article

DNA double strand break repair defects, primary immunodeficiency disorders, and 'radiosensitivity'.

Current opinion in allergy and clinical immunology - 1 Dec 2009

Nahas Shareef A, Gatti Richard A

Abstract excerpt

PURPOSE OF REVIEW: It is important to assess 'radiosensitivity' in patients suspected of immunodeficiency because underlying DNA double strand break (DSB) repair defects have considerable impact on V(D)J recombination, class switching and lymphocyte maturation, leading to increased infections and cancer risk. In addition, the phenotype of 'radiosensitivity' may identify patients with increased toxicity to...

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Source

Identifiers

PMID: 19858715
DOI: 10.1097/ACI.0b013e328332be17

Genes

RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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