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Article

The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas

1 Oct 2012

Abstract excerpt

To evaluate the mechanism of the development of therapeutic resistance after temozolomide treatment, we focused on changes in O(6)-methylguanine DNA methyltransferase (MGMT) and mismatch repair (MMR) between initial and recurrent glioblastomas. Tissue samples obtained from 24 paired histologically confirmed initial and recurrent adult glioblastoma patients who were initially treated with temozolomide were used...

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PMID: 23066447
DOI: 10.1593/tlo.12253

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