Article
Graft-versus-host disease associated T helper cell responses specific for minor histocompatibility antigens are mainly restricted by HLA-DR molecules.
Bone marrow transplantation - 1 Jun 1990
van Els C A, Zantvoort E, Jacobs N, Bakker A, van Rood J J, Goulmy E
Abstract excerpt
Graft-versus-host reactions are mediated by subpopulations of donor T cells and can be attributed to host specific minor histocompatibility (mH) antigens. We isolated strong anti-host mH antigen proliferative T cell lines, LG2, PN2, and LH3, from three patients suffering from acute graft-versus-h...
Topics
- Acute Disease
- Antibodies, Monoclonal
- CD4 Antigens
- Cell Division
- Cell Line
- Graft vs Host Disease
- HLA-DR Antigens
- Humans
- Lymphocyte Activation
- Minor Histocompatibility Antigens
- Pedigree
- Phenotype
- T-Lymphocytes
- T-Lymphocytes, Helper-Inducer