Article
Revealing the genetic structure of a trait by sequencing a population under selection.
Genome research - 1 Jul 2011
Parts Leopold, Cubillos Francisco A, Warringer Jonas, Jain Kanika, Salinas Francisco, Bumpstead Suzannah J, Molin Mikael, Zia Amin, Simpson Jared T, Quail Michael A, Moses Alan, Louis Edward J, Durbin Richard, Liti Gianni
Abstract excerpt
One approach to understanding the genetic basis of traits is to study their pattern of inheritance among offspring of phenotypically different parents. Previously, such analysis has been limited by low mapping resolution, high labor costs, and large sample size requirements for detecting modest effects. Here, we present a novel approach to map trait loci using artificial selection. First, we generated populations...
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