Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity of FCY2 leading to the development of flucytosine resistance in Candida tropicalis.

Antimicrobial agents and chemotherapy - 1 Jun 2011

Chen Yen-Ning, Lo Hsiu-Jung, Wu Chia-Chen, Ko Hui-Ching, Chang Te-Pin, Yang Yun-Liang

Abstract excerpt

As fluconazole resistance becomes an emerging issue for treating infections caused by Candida tropicalis, searching for alternative becomes a prominent task. In the present study, 97 clinical isolates of C. tropicalis were tested for the susceptibilities to flucytosine (5FC) with the Etest method. Although only one isolate was resistant to 5FC, 30 susceptible isolates could produce resistant progeny after...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Antifungal Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to Candida tropicalis

Share to Codon, Nonsense

Share to Drug Resistance, Bacterial

Share to Drug Resistance, Fungal

Share to Loss of Heterozygosity

Source

Open in PubMed Open full text

Identifiers

PMID: 21422221
DOI: 10.1128/AAC.01777-10
PMCID: PMC3101439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity of FCY2 leading to the development of flucytosine resistance in Candida tropicalis.PMID 21422221Read ↗

Nonsense and Missense Mutations in <i>FCY2</i> and <i>FCY1</i> Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of <i>Candida lusitaniae</i>Semantic proximity Read ↗

Recent Increase in the Prevalence of Fluconazole-Non-susceptible Candida tropicalis Blood Isolates in Turkey: Clinical Implication of Azole-Non-susceptible and Fluconazole Tolerant Phenotypes and GenotypingSemantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates.Semantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

An agricultural triazole induces genomic instability and haploid cell formation in the human fungal pathogen Candida tropicalisSemantic proximity Read ↗

Mutational Analysis of Flucytosine Resistance in <i>Candida glabrata</i>Semantic proximity Read ↗

Fluconazole-resistant Candida parapsilosis: fast detection of the Y132F ERG11p substitution, and a proposed microsatellite genotyping scheme.Semantic proximity Read ↗

Clonal population of flucytosine-resistant Candida tropicalis from blood cultures, Paris, France.Semantic proximity Read ↗

Two closely related fluconazole-resistant Candida tropicalis clones circulating in Taiwan from 1999 to 2006.Semantic proximity Read ↗

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.Semantic proximity Read ↗

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.