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An agricultural triazole induces genomic instability and haploid cell formation in the human fungal pathogen Candida tropicalis

1 Apr 2025

Abstract excerpt

The human fungal pathogen Candida tropicalis is widely distributed in clinical and natural environments. It is known to be an obligate diploid organism with an incomplete and atypical sexual cycle. Azole-resistant C. tropicalis isolates have been observed with increasing prevalence in many countries in recent years. Here, we report that tebuconazole (TBZ), a triazole fungicide widely used in agriculture, can...

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PMID: 40168394
DOI: 10.1371/journal.pbio.3003062

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