Fluconazole-resistant Candida parapsilosis: fast detection of the Y132F ERG11p substitution, and a proposed microsatellite genotyping scheme.

doi:10.1016/j.cmi.2024.07.002

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Article

Fluconazole-resistant Candida parapsilosis: fast detection of the Y132F ERG11p substitution, and a proposed microsatellite genotyping scheme.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Nov 2024

Guinea Jesús, Alcoceba Eva, Padilla Eduardo, Ramírez Aída, De Carolis Elena, Sanguinetti Maurizio, Muñoz-Algarra María, Durán-Valle Teresa, Quiles-Melero Inmaculada, Merino Paloma, González-Romo Fernando, Sánchez-García Aída, Gómez-García-de-la-Pedrosa Elia, Pérez-Ayala Ana, Mantecón-Vallejo María Ángeles, Pemán Javier, Cuétara María Soledad, Zurita Nelly Daniela, García-Esteban Coral, Martínez-Jiménez María Del Carmen, Sánchez Castellano Miguel Ángel, Reigadas Elena, Muñoz Patricia, Escribano Pilar

Abstract excerpt

OBJECTIVES: We propose fast and accurate molecular detection of the Y132F ERG11p substitution directly on pure-cultured Candida parapsilosis isolates. We also assessed a discriminative genotyping scheme to track circulating genotypes. METHODS: A total of 223 C. parapsilosis isolates (one patient each) from 20 hospitals, located in Spain and Italy were selected. Isolates were fluconazole-resistant (n = 94;...

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PMID: 39002661
DOI: 10.1016/j.cmi.2024.07.002

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