Article
TGFB1 as a susceptibility gene for high myopia: a replication study with new findings.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Apr 2009
Zha Yi, Leung Kim Hung, Lo Ka Kin, Fung Wai Yan, Ng Po Wah, Shi Ming-guang, Yap Maurice K H, Yip Shea Ping
Abstract excerpt
OBJECTIVE: To investigate the genetic association between transforming growth factor beta1 (TGFB1) gene polymorphisms and high myopia in a Chinese population. METHODS: Six hundred adults were recruited for this case-control study, including 300 subjects with high myopia (-8.0 diopters or worse) and 300 control subjects (within +/-1.0 diopters). Seven tag single-nucleotide polymorphisms (SNPs) and 1 coding SNP...
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