Article
Renin-angiotensin-aldosterone system genotypes and haplotypes affect the susceptibility to nephropathy in type 2 diabetes patients.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2011
Mtiraoui Nabil, Ezzidi Intissar, Turki Amira, Chaieb Molka, Mahjoub Touhami, Almawi Wassim Y
Abstract excerpt
BACKGROUND: The association between renin C-4063T and angiotensinogen (AGT) T174M, M235T, and A-6G polymorphisms with diabetic nephropathy (DN) was investigated in Tunisian type 2 diabetes (T2DM) patients. METHODS: Study subjects comprised 917 T2DM patients (405 normoalbuminuric, 329 microalbuminuric and 185 macroalbuminuric). Genotyping was done by PCR-RFLP. RESULTS: Renin C-4063T allele and genotype frequencies...
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