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Article

Proton pump inhibitors and the risk of overanticoagulation during acenocoumarol maintenance treatment.

British journal of haematology - 1 May 2011

Teichert Martina, van Noord Charlotte, Uitterlinden Andrė G, Hofman Albert, Buhre Peter N, De Smet Peter A G M, Straus Sabine, Stricker Bruno H Ch, Visser Loes E

Abstract excerpt

In the Netherlands, several reports have described a potentiation of acenocoumarol-induced anticoagulation by co-medication of omeprazole or esomeprazole and competitive inhibition of CYP2C19 has been suggested as a possible mechanism for this interaction. We conducted an observational cohort study to investigate the effects of various proton pump inhibitors (PPIs) on acenocoumarol effectiveness. All 2755...

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Source

Identifiers

PMID: 21418179
DOI: 10.1111/j.1365-2141.2011.08633.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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