Article
Acenocoumarol stabilization is delayed in CYP2C93 carriers.
Clinical pharmacology and therapeutics - 1 May 2004
Schalekamp Tom, van Geest-Daalderop Johanna H H, de Vries-Goldschmeding Hanneke, Conemans Jean, Bernsen Mj M j, de Boer Anthonius
Abstract excerpt
OBJECTIVE: Our objective was to assess whether there is an association between the presence of allelic variants of the gene for cytochrome P450 (CYP) 2C9 and anticoagulation problems during the initial 3 to 6 months of acenocoumarol treatment. METHODS: A prospective follow-up study was performed at 2 anticoagulation clinics in the Netherlands. Included subjects started with a standard dose regimen as follows: 6...
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