The composition of T cell subtypes in duodenal biopsies are altered in coeliac disease patients.

doi:10.1371/journal.pone.0170270

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Article

The composition of T cell subtypes in duodenal biopsies are altered in coeliac disease patients.

PloS one - 1 Jan 2017

Steenholt Janni V, Nielsen Christian, Baudewijn Leen, Staal Anne, Rasmussen Karina S, Sabir Hardee J, Barington Torben, Husby Steffen, Toft-Hansen Henrik

Abstract excerpt

One of the hallmarks of Celiac disease (CD) is intraepithelial lymphocytosis in the small intestine. Until now, investigations to characterize the T cell subpopulations within the epithelial layer have not discriminated between the heterodimeric co-receptor molecule, CD8αβ, and the possibly immunoregulatory CD8αα homodimer molecule. Besides TCRαβ+ CD4+ cells, no other phenotypes have been shown to be...

Topics

Adolescent
Adult
B-Lymphocytes
Biomarkers
Biopsy
Case-Control Studies
Celiac Disease
Child
Duodenum
Female
Glutens
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunophenotyping

Intestinal Mucosa

Lymphocyte Count

Male

Middle Aged

Phenotype

Source

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Identifiers

PMID: 28166225
DOI: 10.1371/journal.pone.0170270
PMCID: PMC5293270

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