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Article

Maternal folic acid deficiency stimulates neural cell apoptosis via miR‐34a associated with Bcl‐2 in the rat foetal brain

14 Nov 2018

Abstract excerpt

Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid...

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PMID: 30447272
DOI: 10.1016/j.ijdevneu.2018.11.002

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