Article
HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction.
Journal of human genetics - 1 Jun 2011
Vasilopoulos Yiannis, Sagoo Gurdeep S, Cork Michael J, Walters Kevin, Tazi-Ahnini Rachid
Abstract excerpt
Psoriasis is an inflammatory skin disorder that exhibits multifactorial mode of inheritance. In addition to the well-known susceptibility locus PSORS1 many other loci have been shown to be implicated in the genetic predisposition for disease. However, interactions between loci have not been thoroughly explored. Thus, we measured the effect of potential interaction between human leukocyte antigen (HLA)-C, CSTA and...
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