Article
Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma.
The American journal of surgical pathology - 1 May 2011
Guan Bin, Mao Tsui-Lien, Panuganti Pradeep K, Kuhn Elisabetta, Kurman Robert J, Maeda Daichi, Chen Elizabeth, Jeng Yung-Ming, Wang Tian-Li, Shih Ie-Ming
Abstract excerpt
ARID1A is a recently identified tumor suppressor gene that is mutated in approximately 50% of ovarian clear cell and 30% of ovarian endometrioid carcinomas. The mutation is associated with loss of protein expression as assessed by immunohistochemistry. In this study, we evaluated ARID1A immunoreactivity in a wide variety of carcinomas to determine the prevalence of ARID1A inactivation in carcinomas. Mutational...
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