Article
Transcriptomic Insights into the Antitumor Mechanism of Bufalin in Hepatocellular Carcinoma Cell HepG2
2023-10-30
Abstract excerpt
<h4>Aim: </h4> Bufalin, a cardiotonic steroid derived from Chinese toad venom, exhibits anticancer effects against a variety of malignancies. However, its mechanism of action in human liver cancer remains elusive. This study aimed to elucidate the molecular underpinnings of bufalin's antitumor activity in HepG2 hepatocellular carcinoma (HCC) cells in vitro. Methods HepG2 cells were exposed to 40nM bufalin or 0nM...
Topics
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- Alcohol Consumption and Health Effects
- Berberine and alkaloids research
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Neurobiology and Insect Physiology Research
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- 84470dbb-f13e-539b-9a88-1f767eebccdc
- DOI
- 10.21203/rs.3.rs-3486935/v1
