Article
A role for amyloid in cell aggregation and biofilm formation.
PloS one - 8 Mar 2011
Garcia Melissa C, Lee Janis T, Ramsook Caleen B, Alsteens David, Dufrêne Yves F, Lipke Peter N
Abstract excerpt
Cell adhesion molecules in Saccharomyces cerevisiae and Candida albicans contain amyloid-forming sequences that are highly conserved. We have now used site-specific mutagenesis and specific peptide perturbants to explore amyloid-dependent activity in the Candida albicans adhesin Als5p. A V326N substitution in the amyloid-forming region conserved secondary structure and ligand binding, but abrogated formation of...
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