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Article

Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.

Cancer medicine - 1 Mar 2023

Feng Fan, Zhao Zongqing, Cai Xuechang, Heng Xueyuan, Ma Ximeng

Abstract excerpt

BACKGROUND: Gliomas are a group of primary intracranial tumors with high morbidity and mortality. The previous researches indicated a crucial role of CKS2 (cyclin-dependent kinases regulatory subunit 2) in hepatocellular carcinoma and breast cancer; however, little is known about the molecular mechanism of CKS2 in the tumorigenesis and epithelial-mesenchymal transition-like (EMT) process in glioma. METHODS:...

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Source

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Identifiers

PMID: 36284444
DOI: 10.1002/cam4.5381
PMCID: PMC10028050

Genes

CCK
SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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