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Article

Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2016

Gruszczyk Jakub, Lim Nicholas T Y, Arnott Alicia, He Wen-Qiang, Nguitragool Wang, Roobsoong Wanlapa, Mok Yee-Foong, Murphy James M, Smith Katherine R, Lee Stuart, Bahlo Melanie, Mueller Ivo, Barry Alyssa E, Tham Wai-Hong

Abstract excerpt

Understanding how malaria parasites gain entry into human red blood cells is essential for developing strategies to stop blood stage infection. Plasmodium vivax preferentially invades reticulocytes, which are immature red blood cells. The organism has two erythrocyte-binding protein families: namely, the Duffy-binding protein (PvDBP) and the reticulocyte-binding protein (PvRBP) families. Several members of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26715754
DOI: 10.1073/pnas.1516512113
PMCID: PMC4720341

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