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Article

Progression of lumbar disc degeneration over a decade: a heritability study.

Annals of the rheumatic diseases - 1 Jul 2011

Williams Frances M K, Popham Maria, Sambrook Philip N, Jones Annette F, Spector Tim D, MacGregor Alex J

Abstract excerpt

OBJECTIVES: Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors. METHODS: A 10-year follow-up of MRI-determined LDD was performed in 234 pairs of twin volunteers in the UK and Australia, comprising 90...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21402564
DOI: 10.1136/ard.2010.146001
PMCID: PMC3103702

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