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Article

Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort.

Spine - 1 Nov 2005

Valdes Ana M, Hassett Geraldine, Hart Deborah J, Spector Tim D

Abstract excerpt

STUDY DESIGN: A candidate gene association study in a longitudinal cohort. OBJECTIVE: To investigate the association between polymorphisms at 25 candidate genes and progression of individual radiographic features of lumbar disc degeneration (LDD). SUMMARY OF BACKGROUND DATA: LDD is characterized radiographically by the presence of osteophytes and disc space narrowing and is known to have a genetic component....

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Source

Identifiers

PMID: 16261124
DOI: 10.1097/01.brs.0000184369.79744.a5

Genes

MMP3
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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