Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins.

Arthritis and rheumatism - 1 Feb 1999

Sambrook P N, MacGregor A J, Spector T D

Abstract excerpt

OBJECTIVE: Degenerative intervertebral disc disease is common; however, the importance of genetic factors is unknown. This study sought to determine the extent of genetic influences on disc degeneration by classic twin study methods using magnetic resonance imaging (MRI). METHODS: We compared MRI features of degenerative disc disease in the cervical and lumbar spine of 172 monozygotic and 154 dizygotic twins...

Topics

Adult
Aged
Aged, 80 and over
Cervical Vertebrae
Diseases in Twins
Female
Humans
Intervertebral Disc Displacement
Lumbar Vertebrae
Magnetic Resonance Imaging
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Severity of Illness Index

Twins, Dizygotic

Twins, Monozygotic

Source

Identifiers

PMID: 10025932
DOI: 10.1002/1529-0131(199902)42:2<366::AID-ANR20>3.0.CO;2-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins.PMID 10025932Read ↗

Genetic and environmental effects on disc degeneration by phenotype and spinal level: a multivariate twin study.Semantic proximity Read ↗

Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study.Semantic proximity Read ↗

Heritability of low back pain and the role of disc degeneration.Semantic proximity Read ↗

Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration.Semantic proximity Read ↗

Lumbar disc degeneration: epidemiology and genetic influences.Semantic proximity Read ↗

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study.Semantic proximity Read ↗

Progression and determinants of quantitative magnetic resonance imaging measures of lumbar disc degeneration: a five-year follow-up of adult male monozygotic twins.Semantic proximity Read ↗

The Twin Spine Study: contributions to a changing view of disc degeneration.Semantic proximity Read ↗

Heritability of spinal pain and consequences of spinal pain: a comprehensive genetic epidemiologic analysis using a population-based sample of 15,328 twins ages 20-71 years.Semantic proximity Read ↗

The genetics of intervertebral disc degeneration. Familial predisposition and heritability estimation.Semantic proximity Read ↗

The genetic contribution to radiographic hip osteoarthritis in women: Results of a classic twin studySemantic proximity Read ↗

Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study From TwinsUK.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.