Article
Mucoid Pseudomonas aeruginosa in cystic fibrosis: mutations in the muc loci affect transcription of the algR and algD genes in response to environmental stimuli.
Molecular microbiology - 1 Feb 1990
Deretic V, Govan J R, Konyecsni W M, Martin D W
Abstract excerpt
Increased levels of alginate biosynthesis cause mucoidy in Pseudomonas aeruginosa, a virulence factor of particular importance in cystic fibrosis. The algR gene product, which controls transcription of a key alginate biosynthetic gene, algD, is homologous to the activator members of the two-compo...
Topics
- Alginates
- Carbohydrate Dehydrogenases
- Cystic Fibrosis
- Gene Expression Regulation, Bacterial
- Glycosaminoglycans
- Humans
- Mutation
- Nitrogen
- Polysaccharides, Bacterial
- Promoter Regions, Genetic
- Pseudomonas aeruginosa
- Transcription Factors