Article
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.
Molecular & general genetics : MGG - 1 Jan 1994
Mohr C D, Sonsteby S K, Deretic V
Abstract excerpt
The algD gene encodes NAD-linked GDPmannose dehydrogenase, which is essential for the mucoid phenotype, an important virulence factor expressed by Pseudomonas aeruginosa in cystic fibrosis patients. AlgR, a response regulator controlling mucoidy, is required for high level expression of algD. Ina...
Topics
- Alginates
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Carbohydrate Dehydrogenases
- Cystic Fibrosis
- DNA, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genes, Regulator
- Genetic Linkage
- Glucuronic Acid
- Hexuronic Acids
- Humans
- Hydroxymethylbilane Synthase
- Molecular Sequence Data
- Mutation