Tandemly repeated hexamer sequences within the beta interferon promoter can function as an inducible regulatory element in activation by the adenovirus E1B 19-kilodalton protein.

doi:10.1128/JVI.64.6.3063-3068.1990

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Article

Tandemly repeated hexamer sequences within the beta interferon promoter can function as an inducible regulatory element in activation by the adenovirus E1B 19-kilodalton protein.

Journal of virology - 1 Jun 1990

Shiroki K, Kato H, Kawai S

Abstract excerpt

The expression of the human beta interferon (IFN-beta) gene was activated by the adenovirus E1B-19K protein. The sequence within the IFN-beta promoter which is related to the activation was analyzed by chloramphenicol acetyltransferase (CAT) assay. The repeated hexamer units, present within the region between -109 and -65 relative to the cap site, were required for the activation of the IFN-beta gene by the...

Topics

Adenovirus Early Proteins
Adenoviruses, Human
Base Sequence
Chromosome Deletion
DNA-Binding Proteins
Gene Expression Regulation
Genes, Regulator
Humans
Interferon Type I
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotide Probes

Oncogene Proteins, Viral

Promoter Regions, Genetic

Repetitive Sequences, Nucleic Acid

Transcriptional Activation

Source

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Identifiers

PMID: 2139895
DOI: 10.1128/JVI.64.6.3063-3068.1990
PMCID: PMC249493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2139895-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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