Article
The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.
PLoS genetics - 1 Apr 2020
Setty Bhuvana A, Jinesh Goodwin G, Arnold Michael, Pettersson Fredrik, Cheng Chia-Ho, Cen Ling, Yoder Sean J, Teer Jamie K, Flores Elsa R, Reed Damon R, Brohl Andrew S
Abstract excerpt
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive malignancy. Though the molecular underpinnings of this cancer have been largely unexplored, recurrent chromosomal breakpoints affecting a noncoding region on chr19q13, which includes the chromosome 19 microRNA cluster (C19MC), have been reported in several cases. We performed comprehensive molecular profiling on samples from 14...
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