Snail and the microRNA-200 Family Act in Opposition to Regulate Epithelial-to-Mesenchymal Transition and Germ Layer Fate Restriction in Differentiating ESCs

Abstract excerpt

The reprogramming of somatic cells to inducible pluripotent stem cells requires a mesenchymal-to-epithelial transition. While differentiating ESCs can undergo the reverse process or epithelial-to-mesenchymal transition (EMT), little is known about the role of EMT in ESC differentiation and fate commitment. Here, we show that Snail homolog 1 (Snail) is expressed during ESC differentiation and is capable of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to MicroRNA in disease regulation
• Share to Pluripotent Stem Cells Research
• Share to Tissue Engineering and Regenerative Medicine