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Article

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

11 Mar 2011

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21394101
DOI: 10.1038/cdd.2011.18

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Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasiaPMID 21394101Read ↗

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaksSemantic proximity Read ↗

Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE SyndromeSemantic proximity Read ↗

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.Semantic proximity Read ↗

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169Semantic proximity Read ↗

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumorsSemantic proximity Read ↗

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.Semantic proximity Read ↗

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169Semantic proximity Read ↗

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksSemantic proximity Read ↗

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylationSemantic proximity Read ↗

Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity.Semantic proximity Read ↗

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