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Assembly of Alphavirus Replication Complexes from RNA and Protein Components in a Novel <i>trans</i> -Replication System in Mammalian Cells

10 Mar 2011

Abstract excerpt

For positive-strand RNA viruses, the viral genomic RNA also acts as an mRNA directing the translation of the replicase proteins of the virus. Replication takes place in association with cytoplasmic membranes, which are heavily modified to create specific replication compartments. Here we have expressed by plasmid DNA transfection the large replicase polyprotein of Semliki Forest virus (SFV) in mammalian cells...

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PMID: 21389137
DOI: 10.1128/jvi.00085-11

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