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Article

No association of PTPN22 R620W gene polymorphism with rheumatic heart disease and systemic lupus erythematosus.

Molecular biology reports - 1 Nov 2011

Aksoy Rahime, Duman Türker, Keskin Onur, Düzgün Nurşen

Abstract excerpt

Rheumatic heart disease (RHD) or acute rheumatic fever (ARF) develops as a consequence of an exaggerated immune response to Group A beta haemolytic streptococci causing pharyngitis. The molecular mimicry appears between human cardiac myosin and M protein of group A streptococcal membranes. The polymorphism of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene, which encodes an important negative...

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Source

Identifiers

PMID: 21384170
DOI: 10.1007/s11033-011-0692-7

Genes

RHD
PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No association of PTPN22 R620W gene polymorphism with rheumatic heart disease and systemic lupus erythematosus.PMID 21384170Read ↗

Influence of protein tyrosine phosphatase gene (PTPN22) polymorphisms on rheumatic heart disease susceptibility in North Indian population.Semantic proximity Read ↗

The lack of genetic association of the Toll-like receptor 2 (TLR2) Arg753Gln and Arg677Trp polymorphisms with rheumatic heart disease.Semantic proximity Read ↗

No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey.Semantic proximity Read ↗

PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.Semantic proximity Read ↗

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.Semantic proximity Read ↗

Rheumatic Fever and Rheumatic Heart Disease: Genetics and PathogenesisSemantic proximity Read ↗

Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles.Semantic proximity Read ↗

Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.Semantic proximity Read ↗

The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.Semantic proximity Read ↗

No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.Semantic proximity Read ↗

Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.Semantic proximity Read ↗

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