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Article

No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.

PloS one - 1 Jan 2012

Zhang Qi, Hou Shengping, Jiang Zhengxuan, Du Liping, Li Fuzhen, Xiao Xiang, Kijlstra Aize, Yang Peizeng

Abstract excerpt

BACKGROUND: Behcet's disease is known as a recurrent, multisystem inflammation and immune-related disease. Protein tyrosine phosphatase non-receptor 22 (PTPN22) is a key negative regulator of T lymphocytes and polymorphisms of the PTPN22 gene have been shown to be associated with various immune-related diseases. The present study was performed to assess the association between PTPN22 polymorphisms and Behcet's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

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Identifiers

PMID: 22396730
DOI: 10.1371/journal.pone.0031230
PMCID: PMC3292549

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.PMID 22396730Read ↗

Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease.Semantic proximity Read ↗

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PTPN22 gene polymorphism in Behçet's disease.Semantic proximity Read ↗

PTPN2 rs1893217 single-nucleotide polymorphism is associated with risk of Behçet's disease in a Chinese Han population.Semantic proximity Read ↗

The genetics of Behçet's disease in a Chinese population.Semantic proximity Read ↗

Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.Semantic proximity Read ↗

A variant within intron 1 of the PTPN22 gene decreases the genetic susceptibility of ankylosing spondylitis in a central south Chinese Han population.Semantic proximity Read ↗

A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.Semantic proximity Read ↗

Genetic variants in the JAK1 gene confer higher risk of Behcet's disease with ocular involvement in Han Chinese.Semantic proximity Read ↗

PTPN22 is not associated with Behçet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W.Semantic proximity Read ↗

PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.Semantic proximity Read ↗

Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis.Semantic proximity Read ↗

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