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[Impact of changes in the amino acid sequence of the "a" determinant on the diagnostic capacities of test systems for the detection of HBsAg].

Voprosy virusologii - 1 Jan 2000

Zabelin N N, Kuzina L E, Kudriavtseva E N, Zabotina E E, Braginskiĭ D M, Malyshev N A, Kuzin S N, Samokhvalov E I, L'vov D K

Abstract excerpt

The diagnostic capacities of 4 commercial test systems were comparatively estimated for the detection of HBsAg, by applying a panel of samples with the established amino acid sequence of the "a" determinant of HBsAg. The Roche Elecsys HBsAg test system demonstrated the highest sensitivity - the maximum HBsAg concentrations were found in 19 of 31 cases. Escape mutations in the major hydrophilic region (MHR) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21381337

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