Article
Performance of HBsAg point-of-care tests for detection of diagnostic escape-variants in clinical samples.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2015
Hirzel Cédric, Pfister Stefan, Gorgievski-Hrisoho Meri, Wandeler Gilles, Zuercher Samuel
Abstract excerpt
BACKGROUND: Hepatitis B viruses (HBV) harboring mutations in the a-determinant of the Hepatitis B surface antigen (HBsAg) are associated with reduced reactivity of HBsAg assays. OBJECTIVES: To evaluate the sensitivity and specificity of three HBsAg point-of-care tests for the detection of HBsAg of viruses harboring HBsAg mutations. STUDY DESIGN: A selection of 50 clinical plasma samples containing HBV with HBsAg...
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