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Article

Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice.

Inflammatory bowel diseases - 1 Dec 2011

Samson Charles M, Jurickova Ingrid, Molden Erin, Schreiner William, Colliver Joshua, Bonkowski Erin, Han Xiaonan, Trapnell Bruce C, Denson Lee A

Abstract excerpt

BACKGROUND: Ileal involvement in Crohn's disease (CD) is associated with NOD2 mutations and granulocyte-macrophage colony stimulating factor autoantibodies (GM-CSF Ab), and GM-CSF blockade promotes ileitis in Nod2/Card15-deficient (C15KO) mice. RALDH2-expressing dendritic cells (DC) and IL-4 promote CCR9 imprinting and small bowel homing of T lymphocytes, in conjunction with CCL25 expression by ileal epithelial...

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Source

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Identifiers

PMID: 21381154
DOI: 10.1002/ibd.21672
PMCID: PMC3111853

Genes

CCR9
CCL25
MLN
FOXP3
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice.PMID 21381154Read ↗

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