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Article

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer

15 Mar 2011

Abstract excerpt

Understanding the determinants of resistance of 5-fluorouracil (5FU) is of significant value to optimising administration of the drug, and introducing novel agents and treatment strategies. Here, the expression of 92 genes involved in 5FU transport, metabolism, co-factor (folate) metabolism and downstream effects was measured by real-time PCR low density arrays in 14 patient-derived colorectal cancer xenografts...

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PMID: 21378502
DOI: 10.4161/cbt.11.6.14670

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