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Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway

16 Nov 2020

Abstract excerpt

Keloids are a skin fibroproliferative condition characterized by the hyperproliferation of fibroblasts and the excessive deposition of extracellular matrix (ECM) components. Previous studies have determined that Caveolin‑1 controlled hyperresponsiveness to mechanical stimuli through Runt‑related transcription factor 2 (Runx2) activation in keloids. However, the molecular mechanism of Runx2 regulating the...

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PMID: 33200804
DOI: 10.3892/mmr.2020.11693

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