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Article

Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression.

Journal of dermatological science - 1 Dec 2011

Chua Alvin Wen Choong, Gan Shu Uin, Ting Yixin, Fu Zhenying, Lim Che Kang, Song Colin, Sabapathy Kanaga, Phan Toan Thang

Abstract excerpt

BACKGROUND: Current evidence suggests the potential role of Wnt signalling in keloids pathogenesis but such literature remains scanty. We hypothesize that Wnt signalling is upregulated in keloid fibroblasts (KFs) and this promotes cellular growth, migration and extracellular matrix (ECM) producti...

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Source

Identifiers

PMID: 22005028
DOI: 10.1016/j.jdermsci.2011.09.008

Genes

SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22005028-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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