Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway

12 Jan 2021

Abstract excerpt

Keloids are a type of aberrant skin scarring characterized by excessive accumulation of collagen and extracellular matrix (ECM), arising from uncontrolled wound healing responses. While typically non-pathogenic, keloids are occasionally regarded as a form of benign tumor. CR6-interacting factor 1 (CRIF1) is a well-known CR6/GADD45-interacting protein, that has both nuclear and mitochondrial functions, and also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatologic Treatments and Research
Share to Kruppel-like factors research
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33436666
DOI: 10.1038/s41598-020-79785-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathwayPMID 33436666Read ↗

Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid developmentSemantic proximity Read ↗

Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic modelSemantic proximity Read ↗

Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytesSemantic proximity Read ↗

Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathwaySemantic proximity Read ↗

Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression.Semantic proximity Read ↗

Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloidSemantic proximity Read ↗

BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and FibrogenesisSemantic proximity Read ↗

Molecular dissection of abnormal wound healing processes resulting in keloid diseaseSemantic proximity Read ↗

Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosisSemantic proximity Read ↗

Inhibition of CUB and sushi multiple domains 1 (CSMD1) expression by miRNA-190a-3p enhances hypertrophic scar-derived fibroblast migration in vitroSemantic proximity Read ↗

CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinomaSemantic proximity Read ↗

ZNF469 promotes extracellular matrix production in normal and keloid dermal fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.